Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.
Immune specific genes as well as genes regulating the formation of skin barrier are major determinants for eczema manifestation.There is a debate as to whether allergic sensitization and filaggrin gene (FLG) variants lead to eczema or FLG variants and eczema increase the risk of allergic sensitization.To investigate the time-order between eczema an